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J Am Vet Med Assoc. 2007 Jun 1;230(11):1680-2.

Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration.

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1
Sallisaw Equine Clinic, Sallisaw, OK 74955, USA.

Abstract

OBJECTIVE:

To determine the effects of 8 days of light to heavy exercise on gastric ulcer development in horses and determine the efficacy of omeprazole paste in preventing gastric ulceration.

DESIGN:

Randomized, controlled, multicenter clinical trial.

ANIMALS:

102 horses with normal-appearing gastric mucosa on endoscopic examination that were in light to heavy training.

PROCEDURES:

Horses at 4 trial locations were allocated into replicates and sham dosed orally (empty syringe) or treated with a paste formulation of omeprazole (1 mg/kg [0.45 mg/ lb], PO) once daily for 8 days. Training regimens varied among locations and included early training for western performance events; walking, trotting, and cantering in a mechanical exerciser; and race training (2 locations). Prevalences of gastric ulceration at the completion of the 8-day treatment period were compared between groups.

RESULTS:

At the end of the 8-day treatment period, the proportion of omeprazole-treated horses free from gastric ulceration (88%) was significantly higher than the proportion of sham-dosed horses free from gastric ulceration (27%).

CONCLUSIONS AND CLINICAL RELEVANCE:

Results showed that horses in light to heavy training for as short as 8 days were at risk of developing gastric ulcers and that administration of omeprazole paste decreased the incidence of gastric ulcers.

PMID:
17542738
DOI:
10.2460/javma.230.11.1680
[Indexed for MEDLINE]
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