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Cell. 2007 Jun 1;129(5):861-3.

Filling a GAP(DH) in caspase-independent cell death.

Author information

1
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

Abstract

Mitochondrial outer-membrane permeabilization can lead to cell death even without activation of caspases. In this issue of Cell, Colell et al. (2007) identify the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase as a potent inhibitor of caspase-independent cell death that may allow metabolically active cells to survive mitochondrial insult.

PMID:
17540167
PMCID:
PMC2592604
DOI:
10.1016/j.cell.2007.05.030
[Indexed for MEDLINE]
Free PMC Article

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