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J Proteome Res. 2007 Jul;6(7):2802-11. Epub 2007 Jun 1.

Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.

Author information

1
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom. fsmpp@usc.es

Abstract

There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.

PMID:
17539671
DOI:
10.1021/pr070021t
[Indexed for MEDLINE]

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