Format

Send to

Choose Destination
Clin Pharmacol Ther. 2007 Aug;82(2):204-9. Epub 2007 May 30.

The challenge of treating biofilm-associated bacterial infections.

Author information

1
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

PMID:
17538551
DOI:
10.1038/sj.clpt.6100247
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center