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Bone. 2007 Aug;41(2):162-4. Epub 2007 Apr 21.

Transient precursor strategy or very small biological apatite crystals?

Abstract

The mechanisms of skeletal mineralization have been studied and debated for decades. Recent Raman spectroscopic identification of octacalcium phosphate-like phosphate ions and possibly amorphous calcium phosphate ions in nascent bone mineral were claimed to support a transient precursor strategy for bone apatite formation. However, this data does not refute the theory that the newest, detectable bone mineral is very small, poorly crystalline biological apatite, because non-apatitic phosphate species have previously been identified in biological apatite and detected on the surfaces of nano-sized hydroxyapatite crystals.

PMID:
17537689
DOI:
10.1016/j.bone.2007.04.176
[Indexed for MEDLINE]
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