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Cell Cycle. 2007 Jun 1;6(11):1329-31. Epub 2007 Jun 12.

Circadian clock and breast cancer: a molecular link.

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  • 1Department of Pharmacology, School of Medicine, University of California at Irvine, Irvine, California 92697, USA.

Abstract

The circadian clock controls a large array of behavioral and physiological systems of fundamental importance to most organisms. Consequently, abnormal functioning of the clock results in severe dysfunctions and pathologies. Although epidemiological studies show a clear correlation between disruption of circadian rhythms and incidence of breast cancer, a molecular interpretation of how clock-related mechanisms may link to tumor development remains elusive. Here we speculate on the molecular pathways that may couple the circadian machinery to breast cancer.

PMID:
17534151
DOI:
10.4161/cc.6.11.4295
[PubMed - indexed for MEDLINE]
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