Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2007 Jul;30(7):357-64. Epub 2007 May 25.

Pathological synchronization in Parkinson's disease: networks, models and treatments.

Author information

1
Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2, France.

Abstract

Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).

PMID:
17532060
DOI:
10.1016/j.tins.2007.05.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center