Format

Send to

Choose Destination
See comment in PubMed Commons below
Mech Ageing Dev. 2007 May-Jun;128(5-6):378-82. Epub 2007 Apr 24.

Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.

Author information

1
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA. ross.owen@mayo.edu

Abstract

Genetic variation of the alpha-synuclein gene (SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. The present study identifies an association of common SNCA polymorphisms with disease susceptibility in a series of Irish PD patients. There is evidence for association with alternate regions, of protection and risk which may act independently/synergistically, within the promoter region (Rep1; OR: 0.59, 95% CI: 0.37-0.84) and the 3'UTR of the gene (rs356165; OR: 1.67, 95% CI: 1.08-2.58). Given previous reports of association a collaborative effort is required which may exploit global linkage disequilibrium patterns for SNCA and standardise polymorphic markers used in each population. It is now crucial to identify the susceptibility allele and elucidate its functionality which may generate a therapeutic target for PD.

PMID:
17531291
PMCID:
PMC2970620
DOI:
10.1016/j.mad.2007.04.002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center