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J Mol Cell Cardiol. 2007 Jul;43(1):1-10. Epub 2007 Apr 19.

Kruppel-like Factors (KLFs) in muscle biology.

Author information

1
Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine and University Hospitals of Cleveland / Case Medical Center, Cleveland, OH 44106, USA.

Abstract

The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology.

PMID:
17531262
PMCID:
PMC2743293
DOI:
10.1016/j.yjmcc.2007.04.005
[Indexed for MEDLINE]
Free PMC Article

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