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PLoS Genet. 2007 May 25;3(5):e84.

Recent developments in yeast aging.

Author information

1
Department of Pathology, University of Washington, Seattle, Washington, United States of America. kaeber@u.washington.edu

Abstract

In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in invertebrate eukaryotic model organisms. Of these, single-celled yeast is the least complicated and most amenable to genetic and molecular manipulations. Supporting the use of this organism for aging research, increasing evidence has accumulated that a subset of pathways influencing longevity in yeast are conserved in other eukaryotes, including mammals. Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research.

PMID:
17530929
PMCID:
PMC1877880
DOI:
10.1371/journal.pgen.0030084
[Indexed for MEDLINE]
Free PMC Article

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