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Nat Biotechnol. 2007 Jun;25(6):657-9. Epub 2007 May 27.

Improved antimicrobial peptides based on acyl-lysine oligomers.

Author information

1
Department of Biotechnology & Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.

Abstract

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

PMID:
17529972
DOI:
10.1038/nbt1309
[Indexed for MEDLINE]

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