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J Clin Invest. 1991 Dec;88(6):1785-92.

Role of oxidized low density lipoprotein in atherogenesis.

Author information

1
Department of Medicine, University of California, San Diego, La Jolla 92093.

Abstract

Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

PMID:
1752940
PMCID:
PMC295745
DOI:
10.1172/JCI115499
[Indexed for MEDLINE]
Free PMC Article

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