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Nucl Recept Signal. 2007 May 17;5:e004.

Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.

Author information

1
Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. vadlamudi@uthscsa.edu

Abstract

Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.

PMID:
17525794
PMCID:
PMC1876599
DOI:
10.1621/nrs.05004
[Indexed for MEDLINE]
Free PMC Article
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