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Am J Ophthalmol. 2007 Jun;143(6):1059-60.

Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma.

Author information

1
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Mölndal, Sweden. madeleine.zetterberg@gu.se

Abstract

PURPOSE:

To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG).

DESIGN:

Retrospective case-control association study.

METHODS:

Patients with POAG (n = 242) and controls (n = 187) were analyzed for the APOE epsilon 2/epsilon 3/epsilon 4 polymorphisms using minisequencing technique.

RESULTS:

The Alzheimer-associated APOE epsilon 4 allele had similar frequencies in the POAG group and in the control group. There was no difference between cases and controls with regard to APOE genotypes.

CONCLUSIONS:

If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, POAG and AD, it does not involve APOE polymorphisms.

PMID:
17524782
DOI:
10.1016/j.ajo.2007.01.031
[Indexed for MEDLINE]

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