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Nat Rev Mol Cell Biol. 2007 Jun;8(6):464-78.

Molecular regulation of angiogenesis and lymphangiogenesis.

Author information

1
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK. ralf.adams@cancer.org.uk

Abstract

Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates. Both of these vascular structures are lined with endothelial cells that integrate functionally into different organs, acquire tissue-specific specialization and retain plasticity; thereby, they permit growth during tissue repair or in disease settings. The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication.

PMID:
17522591
DOI:
10.1038/nrm2183
[Indexed for MEDLINE]

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