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FEMS Microbiol Lett. 2007 Jul;272(2):202-5. Epub 2007 May 22.

Evaluation of major membrane protein-II as a tool for serodiagnosis of leprosy.

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1
Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan. yumi@nih.go.jp

Abstract

As serodiagnosis is the easiest way of diagnosing a disease, the utility of Mycobacterium leprae-derived major membrane protein-II (MMP-II), one of the immuno-dominant antigens, in the serodiagnosis of leprosy was examined. The percent positivity by an enzyme-linked immunosorbent assay for anti-MMP-II antibody was 82.4% for multi-bacillary leprosy, and the specificity of the test was 90.1%. For pauci-bacillary leprosy where cell-mediated immunity predominates, 39.0% showed positive results. These percentage values were significantly higher than these values obtained for existing phenolic glycolipid-I based methods, suggesting that MMP-II antibody detection would facilitate the diagnosis of leprosy.

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