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Org Biomol Chem. 2007 Jun 7;5(11):1692-4. Epub 2007 Apr 26.

Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Abstract

Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.

PMID:
17520135
DOI:
10.1039/b703356g
[Indexed for MEDLINE]

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