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Bioorg Med Chem. 2007 Jul 15;15(14):4829-35. Epub 2007 May 6.

Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms.

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Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str, Bl. 9, 1113 Sofia, Bulgaria.


Photodynamic activity of tetrakis-(3-methylpyridyloxy)- and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) toward the gram-positive Staphylococcus aureus, the gram-negative Pseudomonas aeruginosa, and the fungi Candida albicans was studied. The drug uptake dependency with an inverse behavior to the cell density was observed. The cationic photosensitizer completely inactivated S. aureus and C. albicans, and with 4 log10 P. aeruginosa. The photoinactivation at mild experimental conditions, such as drug dose of 1.5 microM and fluence of 50 mW cm(-2) for 10 min irradiation time, was shown.

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