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Arch Pathol Lab Med. 2007 Mar;131(3):440-5.

Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.

Author information

1
Department of Pathology and Laboratory Medicine, Orlando Regional Healthcare, 1414 Kuhl Ave, Orlando, FL 32806, USA. shuan.li@orhs.org

Abstract

CONTEXT:

Serrated adenomas can be morphologically subdivided into traditional and sessile types. They are thought to have a comparable rate of cancer progression like conventional adenomas, but they potentially have a faster rate of growth through methylation pathway(s). They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp.

OBJECTIVE:

To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp.

DATA SOURCES:

Relevant articles in peer-review journals and the authors' working experience as practicing surgical pathologists with a specific interest in gastrointestinal pathology.

CONCLUSIONS:

Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.

[Indexed for MEDLINE]

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