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Autoimmunity. 2007 Jun;40(4):342-4.

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine.

Author information

1
Department of Internal Medicine 3, Institute of Clinical Immunology and Rheumatology, University Hospital Erlangen, Erlangen, Germany. ruediger.muellr@gmx.org

Abstract

Apoptotic cells promote the phagocytosis of themselves via the exposure of "eat me" signals. Furthermore, a second, "find me" signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearance of apoptotic material as factor leading to attraction of phagocytes as a soluble "find me" signal and opsonisation of apoptotic cells as a membrane bound "eat me" signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a "keep calm" mechanism to prevent activation of the immune system by secondary necrosis.

PMID:
17516225
DOI:
10.1080/08916930701356911
[Indexed for MEDLINE]
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