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Nat Biotechnol. 2007 Jun;25(6):660-2. Epub 2007 May 21.

Engineering synthetic signaling proteins with ultrasensitive input/output control.

Author information

1
Program in Biological Sciences, University of California, San Francisco, California 94158-2517, USA.

Abstract

Many signaling proteins are built from simple, modular components, yet display highly complex signal-processing behavior. Here we explore how modular domains can be used to build an ultrasensitive switch--a nonlinear input/output function that is central to many complex biological behaviors. By systematically altering the number and affinity of modular autoinhibitory interactions, we show that we can predictably convert a simple linear signaling protein into an ultrasensitive switch.

PMID:
17515908
DOI:
10.1038/nbt1308
[Indexed for MEDLINE]

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