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Neurology. 2007 May 22;68(21):1837-40.

A new locus for autosomal recessive spastic paraplegia (SPG32) on chromosome 14q12-q21.

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1
INSERM U679, Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital, Paris, France.

Abstract

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterized by progressive spasticity of the lower limbs. Here, we performed a genome-wide linkage analysis on a consanguineous family presenting an autosomal recessive form of HSP associated with mild mental retardation, brainstem dysraphia, and clinically asymptomatic cerebellar atrophy. We have mapped the disease locus SPG32 to chromosome 14q12-q21 within a 30-cM interval, which excludes the atlastin gene.

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