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Arch Dermatol. 2007 May;143(5):599-604.

Susceptibility to UV-A and UV-B provocation does not correlate with disease severity of polymorphic light eruption.

Author information

1
Department of Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. a.s.janssens@lumc.nl

Abstract

OBJECTIVE:

To examine whether the ease of disease provocation by UV-A and/or UV-B radiation correlates with clinical features of polymorphic light eruption (PLE), including those indicative of disease severity.

DESIGN:

Intervention study.

PATIENTS:

One hundred forty-three patients with PLE.

INTERVENTIONS:

Provocation testing with broadband UV-A and UV-B lamps. Additionally, a range of clinical characteristics of the disorder, including a 5-item PLE severity score, was assessed by questionnaire.

MAIN OUTCOME MEASURES:

Percentage of PLE rash induction by UV-A and UV-B provocation, differences between the skin types, and correlation between the results of provocation and a range of clinical characteristics of the disorder, including a 5-item PLE severity score.

RESULTS:

Rash provocation was seen in 78.3% of patients after UV-A and in 46.7% after UV-B exposure. Neither UV-A nor UV-B provocation showed a significant association with the total 5-item severity score. The UV-B reactivity was associated with a high score on the severity item "number of months affected per year" (P = .04), whereas UV-A responsiveness showed a tendency for association with facial involvement (P = .06).

CONCLUSION:

The objective assessment of UV-A or UV-B susceptibility in this large group of patients showed no significant relationship with clinical disease severity.

PMID:
17515509
DOI:
10.1001/archderm.143.5.599
[Indexed for MEDLINE]
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