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Br J Surg. 2007 Jun;94(6):696-701.

Fifteen-year follow-up of a randomized clinical trial of ultrasonographic screening for abdominal aortic aneurysms.

Author information

1
Scott Research Unit, St Richard's Hospital, Chichester, UK. scottunit@rws-tr.nhs.uk

Abstract

BACKGROUND:

Long-term benefits of screening for abdominal aortic aneurysm (AAA) are uncertain. These are the final results of a randomized controlled screening trial for AAA in men, updating those reported previously. Benefit and compliance over a median 15-year interval were examined.

METHODS:

One group of men were invited for ultrasonographic AAA screening, and another group, who received standard care, acted as controls. A total of 6040 men aged 65-80 years were randomized to one of the two groups. Outcome was monitored in terms of AAA-related events (surgery or death).

RESULTS:

In the group invited for screening, AAA-related mortality was reduced by 11 per cent (from 1.8 to 1.6 per cent, hazard ratio 0.89) over the follow-up interval. Screening detected an AAA in 170 patients; 17 of these died from an AAA-related cause, seven of which might have been preventable. The incidence of AAA rupture after an initially normal scan increased after 10 years of follow-up, but was still low overall (0.56 per 1000 person-years).

CONCLUSION:

Screening with a single ultrasonography scan still conferred a benefit at 15 years, although the results were not significant for this population size. Fewer than half of the AAA-related deaths in those screened positive could be prevented.

REGISTRATION NUMBER:

ISRCTN 00079388 (http://www.controlled-trials.com).

PMID:
17514666
DOI:
10.1002/bjs.5780
[Indexed for MEDLINE]

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