Send to

Choose Destination
See comment in PubMed Commons below
Urol J. 2007 Winter;4(1):18-23.

Intravesical Bacillus Calmette-Guerin for treatment of refractory interstitial cystitis.

Author information

  • 1Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.



The aim of this study was to examine the efficacy and safety of intravesical Bacillus Calmette-Guerin (BCG) in the treatment of refractory interstitial cystitis (IC).


Thirteen patients with refractory IC were enrolled in the study. They were scheduled to receive 6 weekly courses of treatment with intravesical BCG. Variables including the frequency, nocturia, urgency, pelvic pain, dyspareunia, dysuria, IC symptom index, IC problem index, and average voided volume were assessed every 6 months after the BCG therapy.


Thirteen patients received the complete course of intravesical BCG therapy. Twenty-four months after the treatment a mean improvement of 51.9% was seen in frequency (P=.001), 43.2% in nocturia (P=.002), 28.7% in urgency (P=.004), 43.1% in pelvic pain (P=.001), 58.3% in dyspareunia (P=.003), 6.5% in dysuria (P=.16), 57.7% in the O'Leary-Sant IC symptom index (P=.001), and 61.8% in the O'Leary-Sant IC problem index (P=.001) scores. A significant improvement was seen in the mean average voided volume at the 24th follow-up month (89.5%; P=.001).


Intravesical BCG is a relatively effective treatment in patients with refractory IC. Its efficacy seems to be modest and lasts for at least 24 months in majority of the patients. It is also safe and well tolerated.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Urology and Nephrology Research Center
    Loading ...
    Write to the Help Desk