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Nat Rev Neurosci. 2007 Jun;8(6):466-79.

Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies.

Author information

1
Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Erratum in

  • Nat Rev Neurosci. 2007 Jul;8(7):568.

Abstract

The enteric nervous system (ENS) has been explored by developmental neurobiologists and medical researchers for decades. Whereas developmental biologists have been unravelling the molecular mechanisms underlying the migration, proliferation and differentiation of the neural crest derivatives that give rise to the ENS, human geneticists have been uncovering the genetic basis for diseases of the ENS, notably Hirschsprung's disease. Here we discuss the exciting recent advances, including novel transgenic and genetic tools, a broadening range of model organisms, and the pursuit of ENS stem cells as a therapeutic tool, that are bringing these fields closer together.

PMID:
17514199
DOI:
10.1038/nrn2137
[Indexed for MEDLINE]

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