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Cancer Cells. 1991 Sep;3(9):341-6.

The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events.

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Biology Department, Brookhaven National Laboratory, Upton, New York 11973.


DNA-PK is a moderately abundant serine/threonine protein kinase found in the nucleus of a wide range of eukaryotic cells. It is one of the few known cellular enzymes whose activity is regulated directly by DNA. Many DNA binding proteins, including a number of transcription factors, are substrates for DNA-PK in vitro. We suggest that this kinase may coordinate signal transduction pathways and nuclear events, including transcription, in response to changes in DNA or chromatin state.

[Indexed for MEDLINE]

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