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Cell. 2007 May 18;129(4):659-62.

Proteasomes: machines for all reasons.

Author information

1
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. george.demartino@utsouthwestern.edu

Abstract

Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome plays a more varied and decisive role in cellular regulation than previously imagined. In this issue, Hanna et al. (2007) expand our view of the proteasome by showing that under certain conditions, proteasome composition can be altered to control ubiquitin homeostasis.

PMID:
17512401
DOI:
10.1016/j.cell.2007.05.007
[Indexed for MEDLINE]
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