Format

Send to

Choose Destination
Biosci Rep. 2007 Jun;27(1-3):39-51.

Disorders of nuclear-mitochondrial intergenomic communication.

Author information

1
Unit of Molecular Neurogenetics, C. Besta Neurological Institute-Foundation IRCCS, via Libero Temolo 4, Milano, 20126, Italy.

Abstract

In the course of evolution, mitochondria lost their independence, and mtDNA became "slave" of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.

PMID:
17510790
DOI:
10.1007/s10540-007-9036-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center