Format

Send to

Choose Destination
See comment in PubMed Commons below
Bioinformatics. 2007 Aug 1;23(15):2015-7. Epub 2007 May 17.

The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family.

Author information

1
Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Abstract

SUMMARY:

The Cytochrome P450 Engineering Database (CYPED) has been designed to serve as a tool for a comprehensive and systematic comparison of protein sequences and structures within the vast and diverse family of cytochrome P450 monooxygenases (CYPs). The CYPED currently integrates sequence and structure data of 3911 and 25 proteins, respectively. Proteins are grouped into homologous families and superfamilies according to Nelson's classification. Nonclassified CYP sequences are assigned by similarity. Functionally relevant residues are annotated. The web accessible version contains multisequence alignments, phylogenetic trees and HMM profiles. The CYPED is regularly updated and supplies all data for download. Thus, it provides a valuable data source for phylogenetic analysis, investigation of sequence-function relationships and the design of CYPs with improved biochemical properties.

ABBREVIATIONS:

Cytochrome P450 Engineering Database, CYPED; cytochrome P450 monooxygenase, CYP; Hidden Markov Model, HMM.

AVAILABILITY:

www.cyped.uni-stuttgart.de

PMID:
17510166
DOI:
10.1093/bioinformatics/btm268
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center