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Nat Rev Cancer. 2007 Jun;7(6):409-13. doi: 10.1038/nrc2145. Epub 2007 May 17.

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation.

Author information

1
Cancer Biology and Genetics Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Abstract

Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear-cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear-cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.

PMID:
17508027
DOI:
10.1038/nrc2145
[Indexed for MEDLINE]

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