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J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):641-3.

Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia.

Author information

1
Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA. nbohnen@umich.edu

Abstract

AIM:

To investigate the relationship between ratings of depressive symptoms and in vivo cortical acetylcholinesterase (AChE) activity in subjects with Parkinson's disease (PD) and parkinsonian dementia (PDem).

METHODS:

Subjects (with PD, n = 18, including subjects with PDem, n = 6, and normal controls, n = 10) underwent [11C]methyl-4-piperidinyl propionate AChE positron emission tomography imaging and clinical assessment including the Cornell Scale for Depression in Dementia (CSDD).

RESULTS:

Subjects with PD and PDem had higher scores on the CSDD compared with normal controls: 7.3 (5.4) and 2.8 (2.6), respectively (F = 6.9, p = 0.01). Pooled analysis demonstrated a significant inverse correlation between cortical AChE activity and CSDD scores: R = -0.5, p = 0.007. This correlation remained significant after controlling for Mini-Mental State Examination scores.

CONCLUSION:

Depressive symptomatology is associated with cortical cholinergic denervation in PD that tends to be more prominent when dementia is present.

PMID:
17507447
PMCID:
PMC2077949
DOI:
10.1136/jnnp.2006.100073
[Indexed for MEDLINE]
Free PMC Article
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