Format

Send to

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 2007 Jul;120(1):144-9. Epub 2007 May 15.

Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood.

Author information

1
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. juan.celedon@channing.harvard.edu

Abstract

BACKGROUND:

There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age.

OBJECTIVES:

To examine the relation between exposure to dust mite allergen and endotoxin at age 2 to 3 months and asthma, wheeze, and atopy in high-risk children.

METHODS:

Birth cohort study of 440 children with parental history of atopy in the Boston metropolitan area.

RESULTS:

In multivariate analyses, early exposure to high levels of dust mite allergen (> or =10 microg/g) was associated with increased risks of asthma at age 7 years (odds ratio [OR], 3.0; 95% CI, 1.1-7.9) and late-onset wheeze (OR, 5.0; 95% CI, 1.5-16.4). Exposure to endotoxin levels above the lowest quartile at age 2 to 3 months was associated with reduced odds of atopy at school age (OR, 0.5; 95% CI, 0.2-0.9). In contrast with its inverse association with atopy, endotoxin exposure in early life was associated with an increased risk of any wheeze between ages 1 and 7 years that did not change significantly with time (hazard ratio for each quartile increment in endotoxin levels, 1.23; 95% CI, 1.07-1.43).

CONCLUSION:

Among children at risk of atopy, early exposure to high levels of dust mite allergen is associated with increased risks of asthma and late-onset wheeze. In these children, endotoxin exposure is associated with a reduced risk of atopy but an increased risk of wheeze.

CLINICAL IMPLICATIONS:

Early endotoxin exposure may be a protective factor against atopy but a risk factor for wheeze in high-risk children.

PMID:
17507083
PMCID:
PMC3737770
DOI:
10.1016/j.jaci.2007.03.037
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center