Optimal cosmetic surgical results are dependent, in part, on the chosen suture material. Given the importance of sutures in wound healing, it is imperative for the esthetic physician to choose the correct suture material. There are a wide variety of suture materials available and each material presents advantages and disadvantages. An ideal suture material has great strength and knot security while remaining elastic with minimal tissue reactivity. Given that there is no single suture material that is ideal for all situations, the cosmetic physician must decide which material is best suited for the particular closure. This review will address the major properties of common suture materials and describe their advantages and disadvantages.