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Genome Biol. 2007;8(5):R82.

Exon arrays provide accurate assessments of gene expression.

Author information

1
Department of Statistics, Stanford University, Stanford, California 94305, USA. kapur@stanford.edu

Abstract

We have developed a strategy for estimating gene expression on Affymetrix Exon arrays. The method includes a probe-specific background correction and a probe selection strategy in which a subset of probes with highly correlated intensities across multiple samples are chosen to summarize gene expression. Our results demonstrate that the proposed background model offers improvements over the default Affymetrix background correction and that Exon arrays may provide more accurate measurements of gene expression than traditional 3' arrays.

PMID:
17504534
PMCID:
PMC1929160
DOI:
10.1186/gb-2007-8-5-r82
[Indexed for MEDLINE]
Free PMC Article

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