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Phys Rev Lett. 2007 Mar 16;98(11):116001. Epub 2007 Mar 14.

Internal mechanical response of a polymer in solution.

Author information

1
Department of Physics, Stanford University, Stanford, California 94305, USA. acohen@post.harvard.edu

Abstract

We observed single molecules of fluorescently labeled double-stranded (ds) lambda DNA held in an anti-Brownian electrokinetic trap. From the measured density fluctuations we extract the density-density response function of the molecule over times >4.5 ms and distances >250 nm, i.e., how a perturbation in density in one part of the molecule propagates through the rest of the molecule. We find a nonmonotonic radial dependence of the relaxation time. In contrast with earlier measurements on freely diffusing dsDNA, we observe clear signs of internal hydrodynamic interactions.

PMID:
17501066
PMCID:
PMC2441641
DOI:
10.1103/PhysRevLett.98.116001
[Indexed for MEDLINE]
Free PMC Article

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