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Eur J Med Chem. 2008 Jan;43(1):210-21. Epub 2007 Apr 2.

Chemoenzymatic synthesis and antimicrobial activity evaluation of monogalactosyl diglycerides.

Author information

1
Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, TS, Italy. cateni@univ.trieste.it

Abstract

Monogalactosyl diglycerides with medium to long fatty acid acyl chains, were prepared and examined for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The study of their in vitro antimicrobial activity confirms the significant activity of some monogalactosyl diacylglycerol analogues and establishes for the galactose series that the 1,2-disubstitution and the octanoyl chain are the proper structural features for the maximum activity.

PMID:
17499886
DOI:
10.1016/j.ejmech.2007.03.012
[Indexed for MEDLINE]

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