Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. Epub 2007 Apr 29.

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

Author information

1
Department of Medicinal Chemistry, Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, USA. apinkerton@kalypsys.com <apinkerton@kalypsys.com>

Abstract

We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.

PMID:
17498954
DOI:
10.1016/j.bmcl.2007.04.076
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center