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Bioorg Med Chem Lett. 2007 Jul 15;17(14):4012-5. Epub 2007 Apr 29.

The discovery of long acting beta2-adrenoreceptor agonists.

Author information

1
Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

Abstract

The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.

PMID:
17498952
DOI:
10.1016/j.bmcl.2007.04.081
[Indexed for MEDLINE]

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