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Clin Nutr. 2007 Aug;26(4):460-5. Epub 2007 May 11.

Effects of protein-rich supplementation and nandrolone on bone tissue after a hip fracture.

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1
Karolinska Institutet, Rheumatology Unit at Karolinska University Hospital/Huddinge, Sweden.

Abstract

BACKGROUND & AIMS:

Osteoporosis is a major health problem worldwide. Low weight is a major risk factor for low bone mass and fractures. The aim of this study was to investigate the effects on bone tissue of protein-rich supplementation alone or in combination with nandrolone decanoate in lean elderly women after a hip fracture.

METHODS:

Sixty elderly women with BMI <24 kg/m(2) admitted to hospital due to a femoral neck fracture were randomised to a control group, to receive a protein-rich formula or to receive the same formula with an addition of nandrolone decanoate for 6 months. All patients received additional calcium and vitamin D. The effects after 6 and 12 months were measured by means of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), and with biochemical bone markers. Osteocalcin and C-terminal telopeptide of collagen-1 (CTX) were used to estimate bone formation and bone resorption, respectively.

RESULTS:

The analyses showed an increase in total body BMD at 6 and 12 months in patients who received protein-rich supplementation. Nandrolone decanoate did not appear to have any additional effect on BMD. Osteocalcin increased in all groups while no significant changes were found for CTX.

CONCLUSION:

The overall results of the study indicated that protein-rich supplementation given to lean elderly female hip fracture patients increased the total body BMD.

PMID:
17498850
DOI:
10.1016/j.clnu.2007.03.007
[Indexed for MEDLINE]
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