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J Bacteriol. 2007 Jul;189(14):5383-6. Epub 2007 May 11.

Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa.

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1
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

Abstract

Quorum sensing (QS) has been previously shown to play an important role in the development of Pseudomonas aeruginosa biofilms (D. G. Davies et al., Science 280:295-298, 1998). Although QS regulation of swarming and DNA release has been shown to play important roles in biofilm development, regulation of genes directly involved in biosynthesis of biofilm matrix has not been described. Here, transcription of the pel operon, essential for the production of a glucose-rich matrix exopolysaccharide, is shown to be greatly reduced in lasI and rhlI mutants. Chemical complementation of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wild-type level and biofilm formation ability. These findings thus connect QS signaling and transcription of genes responsible for biofilm matrix biosynthesis.

PMID:
17496081
PMCID:
PMC1951888
DOI:
10.1128/JB.00137-07
[Indexed for MEDLINE]
Free PMC Article
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