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Clin Oncol (R Coll Radiol). 2007 Aug;19(6):418-26. Epub 2007 May 10.

Hyperthermia: a potent enhancer of radiotherapy.

Author information

1
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. mike@oncology.dk

Abstract

Hyperthermia is generally regarded as an experimental treatment with no realistic future in clinical cancer therapy. This is totally wrong. Although the role of hyperthermia alone as a cancer treatment may be limited, there is extensive pre-clinical data showing that in combination with radiation it is one of the most effective radiation sensitisers known. Moreover, there are a number of large randomised clinical trials in a variety of tumour types that clearly show the potential of hyperthermia to significantly improve both local tumour control and survival after radiation therapy, without a significant increase in side-effects. Here we review the pre-clinical rationale for combining hyperthermia with radiation, and summarise the clinical data showing its efficacy.

PMID:
17493790
DOI:
10.1016/j.clon.2007.03.015
[Indexed for MEDLINE]

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