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Genes Chromosomes Cancer. 2007 Aug;46(8):745-50.

Genomic and functional evidence for an ARID1A tumor suppressor role.

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Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.


ARID1A is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified ARID1A as a presumptive tumor suppressor gene. The transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement, as corroborated in the primary breast carcinoma from which the cDNA had been obtained. In further screening, we identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion involving the 5' end of ARID1A. These studies provide strong evidence that ARID1A is a tumor suppressor gene.

[Indexed for MEDLINE]

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