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Biomech Model Mechanobiol. 2008 Apr;7(2):127-37. Epub 2007 May 10.

Non-linear viscoelastic behavior of abdominal aortic aneurysm thrombus.

Author information

1
Department of Biomedical Engineering, Technische Universiteit Eindhoven, PO box 513, WH4.120, 5600 MB, Eindhoven, The Netherlands.

Abstract

The objective of this work was to determine the linear and non-linear viscoelastic behavior of abdominal aortic aneurysm thrombus and to study the changes in mechanical properties throughout the thickness of the thrombus. Samples are gathered from thrombi of seven patients. Linear viscoelastic data from oscillatory shear experiments show that the change of properties throughout the thrombus is different for each thrombus. Furthermore the variations found within one thrombus are of the same order of magnitude as the variation between patients. To study the non-linear regime, stress relaxation experiments are performed. To describe the phenomena observed experimentally, a non-linear multimode model is presented. The parameters for this model are obtained by fitting this model successfully to the experiments. The model cannot only describe the average stress response for all thrombus samples but also the highest and lowest stress responses. To determine the influence on the wall stress of the behavior observed the model proposed needs to implemented in the finite element wall stress analysis.

PMID:
17492322
PMCID:
PMC2813187
DOI:
10.1007/s10237-007-0080-3
[Indexed for MEDLINE]
Free PMC Article

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