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J Inherit Metab Dis. 1991;14(4):459-77.

Fetal and neonatal bile acid synthesis and metabolism--clinical implications.

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1
Children's Hospital Research Foundation, Cincinnati, Ohio 45229.

Abstract

It has become apparent that with sophisticated technology we are now able to recognize defective bile acid metabolism in a wide variety of disease states. Recognition of specific aberrations, such as inborn errors in bile acid metabolism manifesting as neonatal cholestasis, offers new opportunities for therapeutic intervention. Future studies should determine the incidence of inborn errors in patients with enigmatic and unexplained liver diseases such as idiopathic neonatal hepatitis.

PMID:
1749213
[Indexed for MEDLINE]
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