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Endocr Pract. 2007 Mar-Apr;13(2):194-7.

The stumble-from pipe cleaner to bone builder.

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1
Medical Service, Department of Veterans Affairs, Northern California Health Care System, Martinez, California 94553, USA.

Abstract

OBJECTIVE:

To review the history of the transition of bisphosphonate use from bench chemistry to clinical applications.

METHODS:

Pertinent medical literature, including limited-distribution as well as peer-reviewed publications, was reviewed.

RESULTS:

Bisphosphonates were originally developed to interfere with calcium deposition. An expanded understanding of bone physiology, as well as a growing appreciation of bisphosphonate chemistry, allowed a broadening range of clinical applications.

CONCLUSION:

The use of bisphosphonates in clinical medicine depended on a series of fortuitous events that, at the time, were "stumbles," not unlike the discoveries of Fleming and Newton. The logical sequence is more apparent in retrospect.

PMID:
17490936
DOI:
10.4158/EP.13.2.194
[Indexed for MEDLINE]
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