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Bioorg Med Chem Lett. 2007 Jun 15;17(12):3508-10. Epub 2006 Dec 23.

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst.

Author information

1
Department of Chemistry, Liaoning University of Petroleum and Chemical Technology, Fushun, Liaoning 113001, PR China.

Abstract

A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using chloroacetic acid as catalyst under solvent-free conditions is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of good to excellent yields and short reaction time.

PMID:
17490874
DOI:
10.1016/j.bmcl.2006.12.068
[Indexed for MEDLINE]

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