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J Toxicol Clin Toxicol. 1991;29(4):479-84.

Toxic neonatal effects following maternal clomipramine therapy.

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Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.


Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1). The drug is widely prescribed in Europe and Canada and has been recently approved for use in the USA. Its safety during pregnancy and breastfeeding, however, has not been fully established. Very few reports on its effect on the fetus and neonate have been published (2,3). We report a case of a mother treated with clomipramine during pregnancy, and the side effects observed in the infant. The correlation between plasma clomipramine concentrations in the baby's blood and clinical effects are described. Subsequently, we present the pregnancy outcome of five prospectively collected cases.

[Indexed for MEDLINE]

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