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Biosci Biotechnol Biochem. 2007 May;71(5):1327-9. Epub 2007 May 7.

Egg yolk soluble protein stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

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1
Pharma Foods International Co, Kyoto, Japan.

Abstract

We determined the effects of yolk water-soluble protein (YSP) on bone formation in pre-osteoblastic MC3T3-E1 cells. YSP (50-5,000 microg/ml) increased cell proliferation and collagen content. Alkaline phosphatase (ALP) activity was also increased by YSP treatment. After enhancement of ALP activity, significant augmentation of calcification was observed. These results suggest that YSP is a promising agent for the prevention and treatment of bone loss.

PMID:
17485841
DOI:
10.1271/bbb.60217
[Indexed for MEDLINE]
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