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Front Biosci. 2007 May 1;12:4402-8.

DNA structure and human diseases.

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1
Department of Biochemistry, Indian Institute of Science, Bangalore, India. sathees@biochem.iisc.ernet.in

Abstract

Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.

PMID:
17485384
[Indexed for MEDLINE]
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